PM2.5 NING YURAK BO‘LMACHALARI FIBRILLYATSIYASIGA TA’SIRI: OKSIDATIV STRESS VA ANTIOKSIDANT TERAPIYANING ARITMIYALARNI KAMAYTIRISHDAGI ROLI

Abstract

This  study  investigates  the  impact  of  PM2.5  on  atrial  fibrillation  (AF)  by 
assessing the physiological changes and oxidative stress induced by exposure to fine 
particulate  matter.  Using  an  experimental  model  on  C57BL/6  mice,  the  research 
evaluated key parameters such as heart rate (HR), blood pressure (BP), and reactive 
oxygen species (ROS) levels, comparing them across three groups: control, PM2.5-
exposed,  and  PM2.5  with  antioxidant  therapy  (tempol,  1  mM/L).  Continuous 
monitoring of HR, BP, and ECG was performed with implanted telemetry devices, 
ensuring  precise  tracking  of  AF  episodes.  Results  revealed  that  PM2.5  exposure 
increased HR (540.12 ± 7.21 bpm) and BP (125.36 ± 5.89 mmHg) compared to the 
control group (500.00 ± 6.45 bpm and 110.25 ± 4.78 mmHg, respectively). ROS levels 
also rose significantly in the PM2.5 group (4.538 ± 0.129) relative to control (2.045 ± 
0.074),  indicating  heightened  oxidative  stress.  The  frequency  of  AF  episodes  was 
notably higher in the PM2.5 group (3.125 ± 0.254 episodes per week) compared to the 
control group (0.502 ± 0.132 episodes per week). While antioxidant therapy reduced 
HR, BP, ROS levels, and AF frequency, these values did not fully return to control 
levels, highlighting the partial efficacy of this intervention. The findings suggest that 
PM2.5 exposure exacerbates AF through oxidative stress and autonomic dysfunction, 
while antioxidant therapy shows potential in mitigating these effects. Further research 
is  needed  to  explore  long-term  impacts  and  optimize  intervention  strategies  for 
individuals exposed to air pollution.