THE EFFECT OF URINARY STONE DISEASE ON THE NEPHRON
Keywords:
Key words: Urinary stone disease, Urolithiasis, Nephron function, Obstructive uropathy, Chronic kidney disease (CKD), Renal impairment, Inflammation, Oxidative stressAbstract
Annotation: Urinary stone disease, also known as urolithiasis, is a prevalent medical condition characterized by the formation of calculi within the urinary system. This condition can significantly affect nephron function by inducing structural and functional changes, leading to impaired renal performance. The article discusses the pathophysiology of urinary stone disease, focusing on its impact on nephron segments, including glomeruli and tubules. It highlights mechanisms such as obstructive uropathy, inflammation, ischemia, and oxidative stress, which contribute to nephron damage. The review also explores diagnostic methods, potential complications like chronic kidney disease (CKD), and strategies for prevention and management to mitigate nephron-related damage.
References
1. Khan, S. R., Pearle, M. S., Robertson, W. G., et al. (2016).
"Kidney stones." Nature Reviews Disease Primers, 2(16008).
2. Moe, O. W. (2006).
"Kidney stones: Pathophysiology and medical management." The Lancet, 367(9507), 333-344.
3. Rule, A. D., Lieske, J. C., Li, X., et al. (2014).
"The ROKS nomogram for predicting a second symptomatic stone episode." Mayo Clinic Proceedings, 89(12), 1568-1576.
4. Türk, C., Petrik, A., Sarica, K., et al. (2016).
"EAU guidelines on diagnosis and conservative management of urolithiasis." European Urology, 69(3), 468-474.
5. Sakhaee, K., Maalouf, N. M., Sinnott, B. (2012).
"Kidney stones 2012: Pathogenesis, diagnosis, and management." The Journal of Clinical Endocrinology & Metabolism, 97(6), 1847-1860.
6. Sorokin, I., Mamoulakis, C., Miyazawa, K., et al. (2017).
"Epidemiology of stone disease across the world." World Journal of Urology, 35(9), 1301-1320.
7. Curhan, G. C. (2007).
"Epidemiology of stone disease." Urologic Clinics of North America, 34(3), 287-293.
8. Taylor, E. N., Stampfer, M. J., Curhan, G. C. (2005).
"Dietary factors and the risk of incident kidney stones in men: New insights after 14 years of follow-up." Journal of the American Society of Nephrology, 16(12), 3941-3945.
9. Scales, C. D., Smith, A. C., Hanley, J. M., Saigal, C. S. (2012).
"Prevalence of kidney stones in the United States." European Urology, 62(1), 160-165.
10. Stoller, M. L., Meng, M. V., Abrahams, H. M. (2007).
"Urinary stone disease: The practical guide to medical and surgical management." Springer Science & Business Media.
