FACTORS OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE IN COMBINATION WITH RHEUMATOID ARTHRITIS
Ключевые слова:
Keywords: osteoporosis, coronary heart disease, rheumatoid arthritis, risk factors, cardiovascular diseases, glucocorticosteroids, bone mineral density.Аннотация
ABSTRACT
Rheumatoid arthritis is a systemic disease of unclear etiology with autoimmune
pathogenesis, which is characterized by chronic erosive polyarthritis. In some patients
with rheumatoid arthritis, there is a discrepancy between the processes of bone
resorption and bone formation, which is the cause of secondary metabolic osteopathies.
Such a complication of rheumatoid arthritis with a change in the quality of bone tissue
is osteoporosis. Coronary heart disease in combination with rheumatoid arthritis
exacerbates risk factors leading to a decrease in bone density and an increased risk of
fractures in osteoporosis, which determines the unfavorable course and significantly
worsens the prognosis of the disease. Currently, a number of studies have revealed an
association between an increased risk of osteoporosis (in patients with coronary heart
disease in combination with rheumatoid arthritis) and the following factors: low
mineral bone density, female gender, age over 65 years, early menopause, weight less
than 57 kg, family history of osteoporosis, previous fractures, long-term rheumatoid
arthritis and irrational glucocorticosteroid therapy. This article presents the results of
an analysis of the factors leading to the development of osteoporosis in patients with
coronary heart disease in combination with rheumatoid arthritis who are undergoing
inpatient treatment in the rheumatology department.
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