ARTERIAL HYPERTENSION IN RHEUMATOID ARTHRITIS
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Keywords: rheumatoid arthritis, arterial hypertension, risk factors##article.abstract##
ABSTRACT
The aim is to assess the prevalence and risk factors of arterial hypertension (AH)
in young and middle–aged rheumatoid arthritis (RA) patients.
Material and methods. 222 RA patients (34% with early RA) without
concomitant cardiovascular diseases were examined. The average age was 47±9.7
years; men were 15%; 60% of patients were seropositive for rheumatoid factor (RF),
the average value of DAS 28 was 5.77±1.1, HAQ-DI was 1.58±0.7. Associations
between risk factors and hypertension were analyzed using logistic regression models
adjusted for gender and age.
Results. Hypertension was found in 153 (69.4%) patients (55% in early RA). In
56.3% of patients, an increase in blood pressure was first recorded after the debut of
RA. With hypertension in RA, age (odds ratio [OR] 2.06; 95% confidence interval [CI]
1.51–2.81), seropositivity in the Russian Federation (OR=3.05; 95% CI 1.67–5.57),
abdominal obesity (OR=3.82; 95% CI 1.89–7.71), body mass index (BMI; OR= 1.15;
95% CI 1.07–1.24) and long-term prednisone intake (OR = 1.17; 95% CI 1.03–1.33).
In early RA, the predictors of hypertension were seropositivity in RF (OR=4.62; 95%
CI 1.67–12.82), RF titer (OR=1.43; 95% CI 1.04–1.96), the number of swollen joints
out of 28 (OR=1.14; 95% CI 1.03–1.27), DAS 28 (OR=1.64; 95% CI 1.001–2.67),
HAQ-DI (OR=3.14; 95% CI 1.19–8.25) and BMI (OR=1.14; 95% CI 1.01–1.29).
Conclusion. Hypertension is widespread in patients with RA, including in early RA. In
more than half of cases, hypertension develops against the background of RA and is
associated with traditional risk factors, the presence of RF and long-term use of
prednisone. The contribution of RA characteristics to the development of hypertension
is most clearly seen in early RA. The results obtained indicate the need for early
diagnosis and effective treatment of hypertension in RA with adequate control of
inflammatory activity.
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LITERATURE
1. Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021).
The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The
C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-
2916.
2. Islomovich, S. I. (2024). GENDER CHARACTERISTICS OF THE CURRENT
RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 3-
8.
3. Ilkhom, S. (2023). CAJAM–VOLUME 1. ISSUE 1. 2023. Central Asian Journal
of Advanced Medicine, 1(01), 16-19.
4. Хамраева, Н. А., Султонов, И. И., & Хасанов, Ф. Ш. У. (2019). Кожные
проявления у больных системной красной волчанкой. Вопросы науки и
образования, (28 (77)), 128-131.
5. Sultonov, I. I., Kh, Z. S., Ruzybakieva, M. R., Kireev, V. V., Aripova, T. U., &
Suyarov, A. A. (2021). Pharmacogenetic Aspects of Drug Resistance in
Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4147-4150.
6. Kireev, V. V., & Sultonov, I. I. (2021). Genetic Engineered Preparations-An
Innovative Approach in the Treatment of Rheumatoid Arthritis. Annals of the
Romanian Society for Cell Biology, 4114-4119.
7. Hamraeva, N. A., Sultonov, I. I., & Hasanov, F. S. (2020). Systemic lupus
erythematosus treatment strategy. Journal of Critical Reviews, 7(9), 269-270.
8. Тоиров, А. Э., Султонов, И. И., & Тоиров, Э. С. (2020). ЗНАЧЕНИЕ
ДИСФУНКЦИИ ПОЧЕК У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ
МИОКАРДА НА ФОНЕ САХАРНОГО ДИАБЕТА 2-ГО ТИПА. Вестник
науки и образования, (9-3 (87)), 86-91.
9. Иргашева, У. З., Султонов, И. И., & Тоиров, Д. Р. (2013). Признаки дебюта
системной красной волчанки. Академический журнал Западной Сибири, 9(1),
15-15.
10. Xasanov, F. S., & Sultonov, I. I. (2023). RHEUMATOID ARTHRITIS TREATED
WITH DMARDS AND CARDIOVASCULAR DISEASE RISK. Oriental Journal
of Medicine and Pharmacology, 3(02), 45-52.
11. Нурматова, Л., Султонов, И., & Тоиров, Э. (2011). Эффективность препаратов
пищеварительной активности в комплексном лечении больных хроническим
гепатитом. Журнал проблемы биологии и медицины, (3 (66)), 107-110. 12. Sultonov, I. I., Khamrayev, X. X., & Xasanov, F. SYSTEMIC LUPUS
ERYTHEMATOSUS AND CARDIOVASCULAR PATHOLOGY: WHERE WE
AT?.
13. Sultonov, I. I., Xasanov, F. S., Eshmuratov, S., Uralov, R. S., Shukurova, D., &
Ziyadullayev, S. X. Predictors of Systemic Lupus Erythematosus: A Case-control
Study. International journal of health sciences, 6(S10), 175-182.
14. Khusainova, M. A., Vakhidov, J. J., Khayitov, S. M., & Mamadiyorova, M. M.
(2023). Cardiac arrhythmias in patients with rheumatoid arthritis. Science and
Education, 4(2), 130-137.
15. Khusainova, M. A., Eshmamatova, F. B., Ismoilova, K. T., & Mamadiyorova, M.
M. (2023). METABOLIC SYNDROME IN RHEUMATOID ARTHRITIS AS A
CRITERION OF CARDIOVASCULAR RISK. Oriental renaissance: Innovative,
educational, natural and social sciences, 3(1), 331-339.
16. Alisherovna, K. M., Ismatullayevich, M. A., & Nuriddinovna, E. N. (2024).
FEATURES OF HEART FAILURE IN PATIENTS WITH CORONARY HEART
DISEASE AND THYROTOXICOSIS. Ta'lim innovatsiyasi va
integratsiyasi, 19(4), 52-61.
17. Alisherovna, K. M., Yaxshiboyevich, U. M. R., & Yigitaliyevich, B. A. (2024).
EVALUATION OF A NATRIURETIC PEPTIDE TO OPTIMIZE THE
MANAGEMENT OF COMORBID PATIENTS WITH THYROTOXICOSIS
AND HEART FAILURE. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 62-70.
18. Alisherovna, K. M., Mansurovna, M. D., Erkinovna, N. D., Farxodovna, X. R.,
Toxirovna, M. M., Tolibovna, R. D., & Yorkinovna, E. N. (2024). ARTERIAL
HYPERTENSION AND THYROID STATUS IN PATIENTS OF DIFFERENT
AGES. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 122-129.
19. Alisherovna, K. M., Erkinovna, S. D., Yazdonkulovna, X. M., & Zafarovna, C. M.
M. (2024). ATRIAL FIBRILLATION IN THYROTOXICOSIS–
DETERMINANTS OF DEVELOPMENT AND CONSERVATION. Ta'lim
innovatsiyasi va integratsiyasi, 19(4), 103-113.
20. Alisherovna, K. M., Habibulloyevna, I. M., & Voxidovna, R. F. (2024).
STRUCTURAL AND FUNCTIONAL FEATURES OF THE LEFT VENTRICLE
IN PATIENTS WITH HEART FAILUREIN ISCHEMIC HEART DISEASE AND
THYROTOXICOSIS. Ta'lim innovatsiyasi va integratsiyasi, 19(4), 71-81.
21. Davranovna, M. K. D. K., Alisherovna, K. M., & Erkinovna, K. Z. (2024).
CARDIAC ARRHYTHMIAS IN PATIENTS WITH RHEUMATOID
ARTHRITIS. Spectrum Journal of Innovation, Reforms and Development, 26, 65-
71.
22. Djamshedovna, K. D., Alisherovna, K. M., Xudoyberdiyevich, G. X., &
Rustamovich, T. D. (2023). EFFECTIVENESS OF ANTIHYPERTENSIVE THERAPY IN PREGNANT WOMEN. Spectrum Journal of Innovation, Reforms
and Development, 12, 137-144.
23. Djamshedovna, K. D., & Alisherovna, K. M. (2024). CHANGES IN SOME
SYSTEM INDICATORS IN PREGNANT WOMEN WITH GESTOSIS. Spectrum
Journal of Innovation, Reforms and Development, 25, 111-115.
24. Jamshedovna, K. D., Alisherovna, K. M., Erkinovna, K. Z., & Davranovna, M. K.
(2022). LEFT VENTRICULAR SYSTOLIC DYSFUNCTION IN PREGNANT
WOMEN WITH PRE-ECLAMPSIA WITHOUT PROTEINURIA. Spectrum
Journal of Innovation, Reforms and Development, 10, 135-140.
25. Rustamovich, T. D., Alisherovna, K. M., Djamshedovna, K. D., &
Nizamitdinovich, K. S. (2023). Features of the psychoemotional status of patients
with rheumatoid arthritis. Miasto Przyszłości, 32, 23-30.
26. Alisherovna, K. M., Djamshedovna, K. D., Totlibayevich, Y. S., & Boymamatovna,
E. F. (2022). The Effectiveness of the Original Drug Trimetazidine MV in Patients
with Stable Ischemic Heart Disease and Persistent Angina Attacks Against the
Background of the Use of Trimetazidine Generics. Miasto Przyszłości, 30, 235-238.
27. Alisherovna, K. M., & Djamshedovna, K. D. (2024). AFTER COVID-19
QUALITY OF LIFE. Spectrum Journal of Innovation, Reforms and
Development, 25, 103-110.
28. Alisherovna, K. M., Jamshedovna, K. D., Totlibayevich, Y. S., &
Xudoyberdiyevich, G. X. (2022). FEATURES OF THE QUALITY OF LIFE OF
PATIENTS WITH CHRONIC RENAL FAILURE IN THE TREATMENT OF
HEMODIALYSIS. Spectrum Journal of Innovation, Reforms and Development, 7,
76-81.
29. Rustamovich, T. D., Alisherovna, K. M., Nizamitdinovich, K. S., & Djamshedovna,
K. D. (2022). Gastrointestinal conditions in rheumatoid arthritis patients. Texas
Journal of Medical Science, 15, 68-72.
30. Alisherovna, K. M., Totlibayevich, Y. S., Xudoyberdiyevich, G. X., &
Jamshedovna, K. D. (2022). EFFICACY OF DRUG-FREE THERAPY OF
HYPERTENSION DISEASES IN THE EARLY STAGE OF THE
DISEASE. Spectrum Journal of Innovation, Reforms and Development, 7, 82-88.
