ANALYSIS OF LABORATORY RESULTS IN PATIENTS WITH APLASTIC ANEMIA
##semicolon##
UAC, myelogram, three-stage cytopenia, fatty brain.Abstrak
The material for clinical and laboratory studies in the work were patients with AA (n=86) who sought diagnostic help and subsequent inpatient examination at the republican specialized Scientific and Practical Medical Center of Hematology (RSNPMCG, Tashkent) from 2019 to 2023. Patients with AA ranged in age from 18 to 79 years, while the median age was 40.8±1.8 years. The diagnosis was made taking into account clinical and laboratory data.
The research methods included laboratory examination (general blood test (UAC) and myelogram) and statistical methods of processing the results using the PC application package "OpenEpi 2009, Version 2.3".
##submission.citations##
REFERENCE
1. Abdel Hi M. Z. et al. Platelet indices as a predictor in patients with aplastic anemia and immune thrombocytopenic purpura: a retrospective case–control study //The Egyptian Journal of Internal Medicine. – 2024. – Т. 36. – №. 1. – С. 92.
2. Atta E. H. et al. Predictors of early mortality after rabbit antithymocyte globulin as first-line treatment in severe aplastic anemia //Annals of hematology. – 2017. – Т. 96. – С. 1907-1914.
3. Bacigalupo A. How I treat acquired aplastic anemia //Blood, The Journal of the American Society of Hematology. – 2017. – Т. 129. – №. 11. – С. 1428-1436.
4. Clé D. V. et al. Rabbit antithymocyte globulin dose does not affect response or survival as first-line therapy for acquired aplastic anemia: a multicenter retrospective study //Annals of hematology. – 2018. – Т. 97. – С. 2039-2046.
5. DeZern A. E., Churpek J. E. Approach to the diagnosis of aplastic anemia //Blood Advances. – 2021. – Т. 5. – №. 12. – С. 2660-2671.
6. Killick S. B. et al. Guidelines for the diagnosis and management of adult aplastic anaemia //British journal of haematology. – 2016. – Т. 172. – №. 2.
7. Maciejewski, J. P., Selleri, C., Sato, T., Anderson, S., & Young, N. S. (1996). A severe and consistent deficit in marrow and circulating primitive hematopoietic cells (long-term culture-initiating cells) in acquired aplastic anemia. Blood, 88(6), 1983–1991.
8. Peffault de Latour R. et al. Eltrombopag added to immunosuppression in severe aplastic anemia //New England Journal of Medicine. – 2022. – Т. 386. – №. 1. – С. 11-23.
9. Tembe-Fokunang E. et al. The Scope of Aplastic Anaemia: Etiology, Pathophysiology, Pharmacotherapy and Pharmacoeconomic Impact in Clinical Patient Management //International Journal of Research and Reports in Hematology. – 2022. – Т. 5. – №. 2. – С. 197-214.
10. Young, N. S., Calado, R. T., & Scheinberg, P. (2006). Current concepts in the pathophysiology and treatment of aplastic anemia. Blood, 108(8), 2509–2519.
