TO STUDY THE RELATIONSHIP OF TNFα (G-308A) GENE POLYMORPHISM IN THE DEVELOPMENT OF APLASTIC ANEMIA
##semicolon##
Tumor necrosis factor-α TNFa (rs1800629), single nucleotide polymorphism (SNP), autoimmune disease, proinflammatory cytokine.Abstrak
TNFa genetic polymorphism (rs1800629) is not associated with the risk of aplastic anemia.
##submission.citations##
REFERENCE
1. Alkhuriji A. F. et al. Association of IL-1β, IL-6, TNF-α, and TGFβ1 gene polymorphisms with recurrent spontaneous abortion in polycystic ovary syndrome //Disease Markers. – 2020. – Т. 2020. – №. 1. – С. 6076274.
2. Barnes D. W. H., Mole R. H. Aplastic anaemia in sublethally irradiated mice given allogeneic lymph node cells. – Medical Research Council, Harwell, Eng., 1967.
3. Furlong E., Carter T. Aplastic anaemia: Current concepts in diagnosis and management //Journal of paediatrics and child health. – 2020. – Т. 56. – №. 7. – С. 1023-1028.
4. Hinterberger W. et al. Results of transplanting bone marrow from genetically identical twins into patients with aplastic anemia //Annals of internal medicine. – 1997. – Т. 126. – №. 2. – С. 116-122.
5. Jang H. G. et al. Polymorphisms in tumor necrosis factor-alpha (− 863C> A,− 857C> T and+ 488G> A) are associated with idiopathic recurrent pregnancy loss in Korean women //Human Immunology. – 2016. – Т. 77. – №. 6. – С. 506-511.
6. Luzzatto L, Risitano AM. Advances in understanding the pathogenesis of acquired aplastic anaemia. Br J Haematol. 2018; 182:758–76. doi: 10.1111/bjh.15443.
7. Medinger M. et al. Pathogenesis of acquired aplastic anemia and the role of the bone marrow microenvironment //Frontiers in oncology. – 2018. – Т. 8. – С. 587.
8. Neumann C., Scheffold A., Rutz S. Functions and regulation of T cell-derived interleukin-10 //Seminars in immunology. – Academic Press, 2019. – Т. 44. – С. 101344.
9. Wang X. A. et al. Mesenchymal stem cells in acquired aplastic Anemia: the Spectrum from Basic to Clinical Utility //International Journal of Molecular Sciences. – 2023. – Т. 24. – №. 5. – С. 4464.
10. Zhang Y, Cui X, Ning L, Wei D. The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. Oncotarget. 2017;8(67):111456–69.
Akhmedova Zukhra Bakhtiyarovna, basic doctoral student RSSPMCH, number: +99894 726 87 88.
Matkarimova Dilfuza Saburova, Professor of the Department of Hematology, Transfusiology and Laboratory Science of TMA, number: +99897 412 91 18.
Boboev Kodirjon Tukhtabaevich, Head of the Department of Molecular Medicine and Cellular Technologies of the RSSPMCH, number: +99890 319 39 57.