ANTIMICROBIAL DRUGS AND THEIR USE

Authors

  • Abdiravidov Temurbek Abdimanonovich Author
  • Karimova Mohigul Rahimjon Author
  • Kariyeva Manzura Tulkinovna Author

Keywords:

Keywords: Antibiotics; Antifungals; Dental infections; Antibiotic prophylaxis.

Abstract

Antibiotics play a vital role in dental practice for managing orofacial infections. They are used to manage existing infection and they are also used as prophylaxis for certain medical conditions and surgical procedures. This article will review pharmacological and therapeutic considerations for the proper use of these agents for dental infections. An astounding number of drug classes and formulations are available to manage infections. Fortunately, the microorganisms associated with odontogenic and periodontal infections are well characterized and a relatively small number of antimicrobial agents are required to effectively manage dental infections. With the exception of allergy, adverse effects attributed to these antibiotics are surprisingly infrequent, but most agents are implicated in producing nausea, dyspepsia, and diarrhea. This article will review essential pharmacology of appropriate drug classes and then address clinical considerations for their therapeutic and prophylactic use.

References

1. Drug Facts and Comparisons in Clin-Eguide. New York, NY: Wolters Kluwer Health; 2012.

2. Campagna JD, Bond MC, Schabelman E, Hayes BD. The use of cephalosporins in penicillin-allergic patients: a literature review. J Emerg Med. 2012;42:612–620.

3. Solensky R. Allergy to beta-lactam antibiotics. J Allergy Clin Immunol. 2012;130:1442.

4. Abramowicz M, ed. Cephalosporins for patients with penicillin allergy. Med Lett Drugs Ther. 2012;54:101.

5. Stern RS. Clinical practice. Exanthematous drug eruptions. N Engl J Med. 2012;366:2492–2501.

6. Solensky R, Kahn DA. Drug allergy: an updated practice parameter. Ann Allergy Asthma Immunol. 2010;105:259– 273.

7. Mandell GL, Bennett JE, Dolin R. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa: Churchill Livingston (Elsevier), 2009.

8. Kuriyama T, Karasawa T, Nakagawa K, Yamamoto E, Nakamura S. Incidence of beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of orofacial odontogenic infections. Oral Microbiol Immunol. 2001;16:10–15.

9. Desimone DC, Tleyjeh IM, Correa de Sa DD, et al. Incidence of infective endocarditis caused by viridans group streptococci before and after publication of the 2007 American Heart Association’s endocarditis prevention guidelines. Circulation. 2012;126:60–64.

10. Wilson W, Taubert KA, Gewitz M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007; 116:1736–1754.

11. Ray WA, Murray KT, Hall K, Arbogast PG, Stein CM. Azithromycin and the risk of cardiovascular death. N Engl J Med. 2012;366:1881–1890.

12. Abramowicz M, ed. Miconazole (Oravig) for oropharyngeal candidiasis. Med Lett. 2010;52:95–96.

13. Abramowicz M, ed. Antifungal drugs. Treat Guidel Med Lett. 2012;10:62–63.

14. Gumbo T. General principles of antimicrobial therapy. In: Brunton LL, Chabner BA, Knollmann BC, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12th ed. New York, NY: McGraw-Hill Companies Inc; 2011.

15. Gerding DN, Johnson S. Clostridium difficile-associated disease, including pseudomembranous colitis. In: Longo DL, Fauci AS, Kasper DL, et al, eds. Harrison’s Principles of Internal Medicine. 18th ed. New York, NY: McGraw Hill; 2012.

16. Kelly CP. A 76-year-old man with recurrent Clostridium difficile-associated diarrhea: review of C. difficile infection. JAMA. 2009;301:954–962.

17. Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med. 2002;346:334–339.

18. Abramowicz M, ed. Treatment of Clostridium difficile infection. Med Lett Drugs Ther. 2011;1358:14–15.

19. Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012;307: 1959–1969.

20. Reimers D, Jezek A. The simultaneous use of rifampicin and other antitubercular agents with oral contraceptives. Prax Klin Pneumol. 1971;25:255–262.

21. Sondheimer SJ. Update on oral contraceptive pills and postcoital contraception. Curr Opin Obstet Gynecol. 1992;4: 502–505.

22. Back DJ, Orme ML. Pharmacokinetic drug interactions with oral contraceptives. Clin Pharmacokinet. 1990;18:472– 484.

23. Becker DE. Drug interactions in dental practice: a summary of facts and controversies. Compendium. 1994;15: 1228–1242.

24. Miller DM, Helms SE, Brodell RT. A practical approach to antibiotic treatment in women taking oral contraceptives. J Am Acad Dermatol. 1994;30:1008–1011.

25. Ray WA, Murray KT, Meredith S, Narasimhulu SS, Hall K, Stein CM. Oral erythromycin and the risk of sudden death from cardiac causes. N Engl J Med. 2004;351:1089– 1096.

26. Baillargeon J, Holmes HM, Lin YL, Raji MA, Sharma G, Kuo YF. Concurrent use of warfarin and antibiotics and the risk of bleeding in older adults. Am J Med. 2012;125: 183–189.

27. Kuriyama T, Karasawa T, Nakagawa K, Saiki Y, Yamamoto E, Nakamura S. Bacteriologic features and antimicrobial susceptibility in isolates from orofacial odontogenic infections. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:600–608.

Published

2024-12-04

How to Cite

Abdiravidov Temurbek Abdimanonovich, Karimova Mohigul Rahimjon, & Kariyeva Manzura Tulkinovna. (2024). ANTIMICROBIAL DRUGS AND THEIR USE. ОБРАЗОВАНИЕ НАУКА И ИННОВАЦИОННЫЕ ИДЕИ В МИРЕ, 58(8), 92-105. https://scientific-jl.org/obr/article/view/4680