POLYMORPHISM OF THE MDR1 GENE IN PATIENTS WITH CHRONIC GASTRITIS
Ключевые слова:
Genotyping, polymorphism, chronic gastritis, proton pump inhibitors, pharmacotherapy, polymorphic markersАннотация
The article discusses the results of genotyping patients to improve the pharmacotherapy of acid-dependent diseases of the digestive system by the CYP2C19 gene, which provides the pharmacokinetics of drugs from the proton pump inhibitor group contributed to improving the effectiveness, safety and personalization of pharmacotherapy, which serves to improve the quality of life of patients.
Библиографические ссылки
1. Alexander J. Kvist, Kajsa P. Kanebratt, Anna Walentinsson, Henrik Palmgren,
Matthew O'Hara, Anders Bjerkbom, Linda C. Andersson, Marie Ahlqvist,
Tommy B. Andersson, Critical differences in drug metabolic properties of
human hepatic cellular models, including primary human hepatocytes, stem cell
derived
hepatocytes,
and
hepatoma
cell
lines,
Biochemical
Pharmacology,Volume 155, 2018, Pages 124-140,ISSN 0006-2952,
https://doi.org/10.1016/j.bcp.2018.06.026.
2. Applications for pharmacogenomics in pharmacy practice: A scoping review.
Research in Social and Administrative Pharmacy. Vol. 18, Issue 7, 2022, P.
3094-3118,ISSN 1551-7411.
3. Bernhard Otto Behm, Simone Claudi-Behm, 2 - Gendiagnostik, Editor(s): Birgid
Neumeister, Bernhard Otto Behm, In Klinikleitfaden, Klinikleitfaden
Labordiagnostik (Sechste Ausgabe), Urban & Fischer, 2018, Pages 25-31, ISBN
9783437222351,
https://doi.org/10.1016/B978-3-437-22235-1.00002-4.
4. Demisew G. Factors Associatedwith Gastric Disease Among Students of
Hawassa University: The Caseof College of Agriculture Students.American
Journal of Theoretical and Applied Statistics. 2018; 7 (6); 207-14.
http://doi:10.11648/j.ajtas.20180706.12
5. Musaeva D. M., Ochilova G. S. Surunkali uzoq davom etadigan turlar MDR-1
allel varianti ko ' rish qiymati// Xalq fan-amaliyoti onlayn materialari//XXI asr
tibbiyot intizomi fanning dolzarb muommolari. Toshkent. Uzbekiston. – 2019. -
B. 258-259.
6. Musaeva D. M., Ochilov A. K. farmakoterapiyani individuallashtirish uchun
cyp2c19 genining xususiyatlari// tibbiyotda yangi kun. – 2020. - №1 (29). - P.
65-68.
7. Ochilova G. S., Musaeva D. M.Mdr1 gen polimorfizmining surunkali gastritni
davolash samaradorligiga ta'siri// tibbiyotda yangi kun. - 2020. - T. 1. - №29. -
P. 309-312.
8. Ochilova G. S. glikoprotein-P ning dorivor moddalar tashuvchisining oqsili
sifatida xususiyatlari / / tibbiyotda yangi kun. – 2020. - T. 2. - №30/2. - P. 60
53.
9. Ochilov A. K. gastroenterologiya uchun sitokrom P450 ning ahamiyati / /
tibbiyotda yangi kun. – 2020. - №2 (30/2). - 57-59 betlar
10. Fricke-Galindo,
H.
Jung-Cook,
A. LLerena, M. Leіpez-Leіpez,
Farmacogenetica de reacciones adversas a fermacos antiepilepticos, Neurologia,
Volume 33, Issue 3, 2018, Pages 165-176, ISSN 0213-4853,
https://doi.org/10.1016/j.nrl.2015.03.005.
11. Joseph F. Goldberg, Charles B. Nemeroff, Chapter 9 - Pharmacogenomics and
antidepressants: efficacy and adverse drug reactions, Editor(s): Evangelia Eirini
Tsermpini, Martin Alda, George P. Patrinos, In Translational and Applied
Genomics, Psychiatric Genomics, Academic Press, 2022, Pages 189-202, ISBN
9780128196021,
https://doi.org/10.1016/B978-0-12-819602-1.00011-5.
12. Klotz U, Schwab M, Treiber G. CYP2C19 polymorphism and proton pump
inhibitors. Basic Clin. Pharmacol. Toxicol., 2004. 95: 2–8.
13. 87. Livak, Kenneth J. and Thomas D. Schmittgen. “Analysis of relative gene
expression data using real-time quantitative PCR and the 2(-Delta Delta C(T))
Method.” METHODS 25 4 (2001): 402-8
14. Ochilova G. S. farmakoterapiyada shaxsiylashtirish uchun mdr1 genining o'ziga
xos xususiyati / / xalqaro ishtirokdagi III Butunrossiya ilmiy-amaliy
konferentsiyasining tezislari to'plami / / Farmakoterapiya xavfsizligi: NOLI
NOCERE!. Qozon. Rossiya. - 2020. - P. 161-162.
15. Ochilov A. K. surunkali gastritni davolash samaradorligiga cyp2c19 genining
ta'siri / / xalqaro ishtirokdagi III Butunrossiya ilmiy-amaliy konferentsiyasining
tezislari to'plami / / Farmakoterapiya xavfsizligi: NOLI NOCERE! Qozon.
Rossiya. – 2020. - P. 160-161.
