VIRUSLI GEPATIT A KASALLIGI RIVOJLANISHIGA TA’SIR ETUVCHI XAVF OMILLARI VA ULARGA QARSHI PROFILAKTIK CHORA-TADBIRLARNI YAXSHILASH

##article.authors##

  • A.A. Nematov ##default.groups.name.author##
  • D. Berdimuradov ##default.groups.name.author##

##semicolon##

Kalit so’zlar:VGA, xavf omillar, profilaktika, tarqalganlik darajasi, absolyut xavf, nisbiy xavf

##article.abstract##

Muammonig zarurati va dolzarbligi: Gepatit A virusi (VGA) butun dunyo bo'ylab endemik hisoblanadi, ammo tez tez epidemiyalar ham sodir bo'lishi mumkin. Haddan tashqari gavjum va yomon sanitariya holatiga ega bo'lgan hududlarda ushbu virus kattalar orasida ham keng miqyosda tarqalishi mumkin. Infektsiyaning klinik oqibatlari yoshga bog'liq bo’lib asosan yosh bolalarda kasallik asimptomatik tarzda namoyon bo’ladi.

##submission.citations##

1. Lemon S. M., Ott J. J., Van Damme P., Shouval D. Type A viral hepatitis: a summary and update on the molecular virology, epidemiology, pathogenesis and prevention. Journal of Hepatology . 2018;68(1):167–184. doi: 10.1016/j.jhep.2017.08.034.

2. Wang X., Pan Y., Chen J., et al. The excretion rate and stability of HAAg in human fecal samples after live attenuated hepatitis A vaccination. Journal of Medical Virology . 2020;92(12):3312–3318. doi: 10.1002/jmv.25747.

3. González-López O., Rivera-Serrano E. E., Hu F., et al. Redundant late domain functions of tandem VP2 YPX3L motifs in nonlytic cellular egress of quasi-enveloped hepatitis A virus. Journal of Virology . 2018;92(23):e01308–e01318.

4. Williford S. E., Lemon S. M. Clinical Virology . 2016. Hepatitis A virus; pp. 1165–1188. Kulsuptrakul J., Wang R., Meyers N. L., Ott M., Puschnik A. S. A genome-wide CRISPR screen identifies UFMylation and TRAMP-like complexes as host factors required for hepatitis A virus infection. Cell Reports . 2021;34(11) doi: 10.1016/j.celrep.2021.108859.108859

5. Watanabe S., Morimoto N., Miura K., et al. Full-genome characterization of the RIVM-HAV16-090-like hepatitis A virus strains recovered from Japanese men who have sex with men, with sporadic acute hepatitis A. Hepatology Research . 2019;49(5):521–530. doi: 10.1111/hepr.13313.

6. Lanford R. E., Walker C. M., Lemon S. M. Nonhuman primate models of hepatitis A virus and hepatitis E virus infections. Cold Spring Harbor Perspectives in Medicine . 2019;9(2) doi: 10.1101/cshperspect.a031815.a031815

7. Desbois D., Couturier E., Mackiewicz V., et al. Epidemiology and genetic characterization of hepatitis A virus genotype iia. Journal of Clinical Microbiology . 2010;48(9):3306–3315. doi: 10.1128/jcm.00667-10.

8. Lemon S. M., Ott J. J., Van Damme P., Shouval D. Type A viral hepatitis: a summary and update on the molecular virology, epidemiology, pathogenesis and prevention. Journal of Hepatology . 2018;68(1):167–184. doi: 10.1016/j.jhep.2017.08.034.

##submissions.published##

2024-11-05