THE EFFECTIVENESS OF THE TREATMENT OF PSORIATIC ARTHRITIS
Keywords:
Keywords: psoriatic arthritis, leflunomide, psoriasisAbstract
ABSTRACT
Goal. To evaluate the efficacy and tolerability of leflunomide, administered at a
dose of 100 mg/ day for 3 days and 20 mg / day for 6 months, in patients with an active
form of psoriatic arthritis (PA).
Materials and methods. An open, uncontrolled study was conducted. 15 patients
aged 37 to 60 years were examined, the duration of arthritis averaged 7.4 years.
Leflunomide was prescribed at 100 mg / day for the first 3 days, and then 20 mg / day
for 6 months. The dynamics of the number of painful and swollen joints, the severity
of pain and the activity of the disease were evaluated on a visual analog scale, The
Likert scale is both in the opinion of the doctor and the patient himself.
Results. Against the background of leflunomide treatment, there was a
significant decrease in the number of painful and swollen joints by 54.3 and 65.7%,
respectively. The high efficacy of leflunomide according to the PsARC (Psoriatic
Arthritis Response Criteria) and ACR 50 (American College of Rheumatology) criteria
was noted in 86.7% of cases, which makes it possible to recommend it to patients with
a polyarticular form of the disease. The tolerability of leflunomide was assessed as
satisfactory. In 3 patients, therapy was canceled due to the development of leukopenia
and urticaria.
Conclusion. High efficacy of leflunomide has been demonstrated in patients with
polyarticular PA.
References
LITERATURE
1. Ibragimov, K., Sultonov, I., & Ravshanova, M. (2024). The Effectiveness of the Combination Therapy with biologic DMARDS in Rheumatoid Arthritis. Frontiers of Global Science, 2(1), 17-24.
2. Ziyadullaev, S. K., Sultonov, I. I., Dushanova, G. A., & Akbarovna, K. S. (2021). The Effectiveness Of Pharmacotherapy For Dmards With Ra Depending On The C3435t Polymorphism Of The Mdr1 Gene. Int. J. of Aquatic Science, 12(3), 2908-2916.
3. Sobirov, A., & Sultonov, I. (2024). COMPREHENSIVE ANALYSIS OF CLINICAL NEUROPSYCHOLOGICAL AND NEUROIMAGING ASPECTS OF ALZHEIMER'S DISEASE. Frontiers of Global Science, 2(1).
4. Islomovich, S. I., Alisherovna, K. M., & Djamshedovna, K. D. (2024). FACTORS OF OSTEOPOROSIS IN PATIENTS WITH CORONARY HEART DISEASE IN COMBINATION WITH RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 132-138.
5. Islomovich, S. I. (2024). GENDER CHARACTERISTICS OF THE CURRENT RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 3-8.
6. Islomovich, S. I. (2024). FEATURES OF THE COURSE OF PREGNANCY IN RHEUMATOID ARTHRITIS. International journal of medical sciences, 4(10), 77-84.
7. Djamshedovna, K. D., Alisherovna, K. M., & Islomovich, S. I. (2024). ARTERIAL HYPERTENSION IN RHEUMATOID ARTHRITIS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 139-145.
8. Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). THERAPY OF RHEUMATOID ARTHRITIS DURING PREGNANCYTHE. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 172-180.
9. Nizamitdinovich, K. S., Alisherovna, K. M., & Islomovich, S. I. (2024). CLINICAL COURSE OF BRONCHIAL ASTHMA IN PATIENTS WITH THYROID DISEASES. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 181-187.
10. Alisherovna, K. M., Islomovich, S. I., & Djamshedovna, K. D. (2024). PSYCHOEMOTIONAL STATE AND QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 124-131.
11. Ilkhom, S. (2023). CAJAM–VOLUME 1. ISSUE 1. 2023. Central Asian Journal of Advanced Medicine, 1(01), 16-19.
12. Alisherovna, K. M., Nizamitdinovich, K. S., & Islomovich, S. I. (2024). FEATURES OF BONE MINERAL DENSITY IN PATIENTS WITH DISEASES OF THE DIGESTIVE SYSTEM. Ta'lim innovatsiyasi va integratsiyasi, 31(2), 162-171.
13. Sultonov, I. I., Xasanov, F. S., Eshmuratov, S., Uralov, R. S., Shukurova, D., & Ziyadullayev, S. X. Predictors of Systemic Lupus Erythematosus: A Case-control Study. International journal of health sciences, 6(S10), 175-182.
14. Xasanov, F. S., & Sultonov, I. I. (2023). RHEUMATOID ARTHRITIS TREATED WITH DMARDS AND CARDIOVASCULAR DISEASE RISK. Oriental Journal of Medicine and Pharmacology, 3(02), 45-52.
15. Иргашева, У. З., Султонов, И. И., & Тоиров, Д. Р. (2013). Признаки дебюта системной красной волчанки. Академический журнал Западной Сибири, 9(1), 15-15.
16. Hamraeva, N. A., Sultonov, I. I., & Hasanov, F. S. (2020). Systemic lupus erythematosus treatment strategy. Journal of Critical Reviews, 7(9), 269-270.
17. Kireev, V. V., & Sultonov, I. I. (2021). Genetic Engineered Preparations-An Innovative Approach in the Treatment of Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4114-4119.
18. Тоиров, А. Э., Султонов, И. И., & Тоиров, Э. С. (2020). ЗНАЧЕНИЕ ДИСФУНКЦИИ ПОЧЕК У БОЛЬНЫХ ОСТРЫМ ИНФАРКТОМ МИОКАРДА НА ФОНЕ САХАРНОГО ДИАБЕТА 2-ГО ТИПА. Вестник науки и образования, (9-3 (87)), 86-91.
19. Sultonov, I. I., Kh, Z. S., Ruzybakieva, M. R., Kireev, V. V., Aripova, T. U., & Suyarov, A. A. (2021). Pharmacogenetic Aspects of Drug Resistance in Rheumatoid Arthritis. Annals of the Romanian Society for Cell Biology, 4147-4150.
20. Хамраева, Н. А., Султонов, И. И., & Хасанов, Ф. Ш. У. (2019). Кожные проявления у больных системной красной волчанкой. Вопросы науки и образования, (28 (77)), 128-131.
21. Sherbek o‘g‘li, U. R., & Ismailovich, N. A. (2024). REVMATOID ARTRIT KASALLIGIDA METABOLIK REGULYASIYA. Научный Фокус, 2(19), 429-434.
22. Sherbek o‘g‘li, U. R., & Ismailovich, N. A. (2024). REVMATOID ARTRITDA STEROID DIABET OLDINI OLISH. Научный Фокус, 2(19), 425-428.
23. Sherbek o‘g‘li, U. R., & Ismailovich, N. A. (2024). REVMATOID ARTRIT KASALLIGIDA METORTRIT VA NOSTEROIDLARNI BIRGA QOLLASHDA TERAPEVTIK SAMARADORLIK. Научный Фокус, 2(19), 418-424.
24. Sherbek o‘g‘li, U. R., & Ismailovich, N. A. (2024). TIZIMLI QIZIL YUGURIK KASALLIGI. Научный Фокус, 2(19), 413-417.
25. Sherbekovich, U. R., & Eldorovich, E. S. (2024). PROFILE OF AUTOANTIBODIES IN SYSTEMIC SCLERODERMA. International journal of medical sciences, 4(05), 257-265.
26. Eldorovich, E. S., & Sherbekovich, U. R. (2024). THE CLINICAL SIGNIFICANCE OF INTERLEUKIN-4 IN SYSTEMIC SCLERODERMA. Spectrum Journal of Innovation, Reforms and Development, 27, 51-58.
27. Sherbekovich, U. R., & Eldorovich, E. S. (2024). SEVERITY INDEX IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS. Spectrum Journal of Innovation, Reforms and Development, 27, 75-82.
28. Eldorovich, E. S., & Sherbekovich, U. R. (2024). DYNAMIC CHANGES IN THE ACTIVITY INDEX AND THE TOTAL SEVERITY INDEX IN PATIENTS WITH SYSTEMIC SCLERODERMA AND INTERSTITIAL LUNG DISEASE OVER A 5-YEAR FOLLOW-UP PERIOD. International journal of medical sciences, 4(05), 281-289.
29. Sherbekovich, U. R. (2024). FEATURES OF ANKYLOSING SPONDYLITIS IN MEN AND WOMEN. International journal of medical sciences, 4(11), 156-162.
30. Eldorovich, E. S. (2024). The Effect of Nonsteroidal Anti-Inflammatory Drugs on the Progression of Sacroiliitis in Patients With Axial Spondyloarthritis. Miasto Przyszłości, 54, 613-618.
31. Mamasoliyevna, D. N., Alisherovna, K. M., & Totlibayevich, Y. S. (2023). Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease: the Facets of Conjugacy. Miasto Przyszłości, 35, 166-173.
32. Alisherovna, K. M., Alisherovich, B. Z., Ilyosxonovich, K. I., & Oybekovna, E. E. (2022). Changes In Hemodynamics Of The Cardiovascular System In Patients With Fibrosis Alveolitis. Spectrum Journal of Innovation, Reforms and Development, 4, 203-209.
33. Alisherovna, K. M., Kamoliddinovna, I. M., Baxtiyorovna, O. K., Ikromovna, E. N., & Faxriddinovich, J. I. (2023). AFTER COVID-19 QUALITY OF LIFE. Open Access Repository, 9(12), 305-311.
34. Alisherovna, K. M., Baxtiyorovich, Z. M., & Anvarovich, N. J. (2022). To Assess The Condition Of The Myocardium In Patients Chronic Heart Failure On The Background Of Rheumatoid Arthritis. Spectrum Journal of Innovation, Reforms and Development, 4, 210-215.
35. Alisherovna, M. K. Stages Of Development Of Renal Dysfunction And Anemia In Patients With Chronic Heart Failure. International Journal of Innovations in Engineering Research and Technology, 8(05), 50-53.
36. Alisherovna, K. M. (2022). PSYCHOSOMATIC CHARACTERISTICS OF PATIENTS WITH RHEUMATOID ARTHRITIS AND GOUT. Galaxy International Interdisciplinary Research Journal, 10(5), 665-671.
37. Alisherovna, K. M., Akmalovna, K. N., & Mamasoliyevna, D. N. (2022). Kidney dysfunction in chronic heart failure. Texas Journal of Medical Science, 13, 104-109.
38. Mamasoliyevna, D. N., Akmalovna, K. N., & Alisherovna, K. M. (2022). Quality of Life Depending on Gender. The Peerian Journal, 11, 71-77.
