SURGICAL PALLIATIVE AND SYMPTOMATIC TREATMENT OF REGIONAL CANCER OF THE CARDIOESOPHAGEAL JUNCTION

Mualliflar

  • KULIEV Aziz Abdumazhidovich. ##default.groups.name.author##
  • KHUJAKULOV Shakhriyor Shokirovich ##default.groups.name.author##

##semicolon##

The key words: cancer of the cardioesophageal junction, stenting, cytoreductive palliative resection surgery

Abstrak

 
Annotation: The article deals with the issues regarding the optimization of surgical 
treatment strategies in regional and metastatic cancer of the cardioesophageal junction 
which  result  in  elimination  of  gastric  fistulas.  Short-  and  long-term  effects  of  238 
surgeries  between  1990  and  2010  have  been  studied.  The  benefits  of  surgical  and 
endoscopic esophageal stenting over gastrostomy have been reported. The indication 
for  and  esophageal  stent  placement  procedures  have  been  defined.  The  article 
concludes that cytoreductive transpleural resection surgeries were not as- sociated with 
increased post-operative mortality. However, they resulted in prolongation of patient`s 
lives and creating proper conditions for delivering adjuvant chemotherapy. 

##submission.citations##

LIST OF REFERENCES

1. Aggarwal C. et al. A phase 1, open-label, dose-escalation study of enoblituzumab

in combination with pembrolizumab in patients with select solid tumors // J.

Immunother. Cancer. - 2018. - Т. 6. - №. Suppl. 2. - С. 114.

2. Aleksander S. A. et al. The Gene Ontology knowledgebase in 2023 // Genetics. -

2023. - Т. 224. - №. 1. - С. iyad031.

3. Baj J. et al. Immunological aspects of the tumor microenvironment and epithelial-

mesenchymal transition in gastric carcinogenesis // International journal of

molecular sciences. - 2020. - Т. 21. - №. 7. - С. 2544.

4. Chen L. et al. Cancer associated fibroblasts promote renal cancer progression

through a TDO/Kyn/AhR dependent signaling pathway // Frontiers in Oncology. -

2021. - T. 11. - C. 628821.

5. Chen P., He Y., Zhou C. P47. 13 Galectin-9, A Novel Prognostic Factor in Small

Cell Lung Cancer // Journal of Thoracic Oncology. - 2021. - T. 16. - №. 3. - C.

S498.

6. Chocarro L. et al. Understanding LAG-3 signaling // International journal of

molecular sciences. - 2021. - T. 22. - №. 10. - C. 5282.

7. Compagno D. et al. Galectins as checkpoints of the immune system in cancers, their

clinical relevance, and implication in clinical trials // Biomolecules. - 2020. T. 10. -

№. 5. - C. 750.

8. Cui J. et al. Pancancer analysis of revealed TDO2 as a biomarker of prognosis and

immunotherapy //Disease Markers. - 2022. - T. 2022. - C. 1-18.

9. Doroshow D. B. et al. PD-L1 as a biomarker of response to immune-checkpoint

inhibitors // Nature reviews Clinical oncology. - 2021. - T. 18. - №. 6. - C. 345362.

10. Edwards D. R., Handsley M. M., Pennington C. J. The ADAM metalloproteinases//

Molecular aspects of medicine. - 2008. - T. 29. - №. 5. - C. 258-289.

11. Elad-Sfadia G. et al. Galectin-3 augments K-Ras activation and triggers a Ras signal

that attenuates ERK but not phosphoinositide 3-kinase activity // Journal of

Biological Chemistry. - 2004. - T. 279. - №. 33. - C. 34922-34930.

12. Gooz M. ADAM-17: the enzyme that does it all // Critical reviews in biochemistry

and molecular biology. - 2010. - T. 45. - №. 2. - C. 146-169.

13. Gu L. et al. PD-L1 and gastric cancer prognosis: A systematic review and

metaanalysis // PloS one. - 2017. - T. 12. - №. 8. - C. e0182692.

14. He W. et al. CD155T/TIGIT signaling regulates CD8+ T-cell metabolism and

promotes tumor progression in human gastric cancer // Cancer research. - 2017. -T.

77. - №. 22. - C. 6375-6388.

15. Henson D. E. et al. Differential trends in the intestinal and diffuse types of gastric

carcinoma in the United States, 1973-2000: increase in the signet ring cell type //

Archives of pathology & laboratory medicine. - 2004. - T. 128. - №. 7. - C. 765770.

16. Heusschen R., Griffioen A. W., Thijssen V. L. Galectin-9 in tumor biology: a jack

of multiple trades // Biochimica et Biophysica Acta (BBA)-Reviews on Cancer. -

2013. - T. 1836. - №. 1. - C. 177-185.

17. Huang D. W. et al. CD155 expression and its correlation with clinicopathologic

characteristics, angiogenesis, and prognosis in human cholangiocarcinoma //

OncoTargets and therapy. - 2017. - C. 3817-3825.

18. Iguchi-Manaka A. et al. Increased soluble CD155 in the serum of cancer patients //

PloS one. - 2016. - T. 11. - №. 4. - C. e0152982.

19. Joossens J. V. et al. Dietary salt, nitrate and stomach cancer mortality in 24

countries. European Cancer Prevention (ECP) and the INTERSALT Cooperative

Research Group // International journal of epidemiology. - 1996. - T. 25. - №. 3. -

c. 494-504.

20. Keir M. E. et al. PD-1 and its ligands in tolerance and immunity // Annu. Rev.

Immunol. - 2008. - T. 26. - № 1. - C. 677-704.

21. Kim S. J. et al. Fascin expression is related to poor survival in gastric cancer //

Pathology international. - 2012. - T. 62. - №. 12. - C. 777-784.

22. Larsson S. C., Bergkvist L., Wolk A. Fruit and vegetable consumption and

incidence of gastric cancer: a prospective study // Cancer Epidemiology Biomarkers

& Prevention. - 2006. - T. 15. - №. 10. - C. 1998-2001.

23. Lee B. H. et al. Prognostic value of galectin-9 relates to programmed death-ligand

1 in patients with multiple myeloma // Frontiers in Oncology. - 2021. - T. 11. - C.

669817.

24. Li F. et al. CD4/CD8+ T cells, DC subsets, Foxp3, and IDO expression are

predictive indictors of gastric cancer prognosis // Cancer medicine. - 2019a. - T. 8.

- №. 17. - C. 7330-7344.

25. Li Y. C. et al. Overexpression of an immune checkpoint (CD155) in breast cancer

associated with prognostic significance and exhausted tumor-infiltrating

lymphocytes: a cohort study // Journal of immunology research. - 2020. - T. 2020.

- C. 1-9.

26. Li Y. et al. B7-H3 increases the radioresistance of gastric cancer cells through

regulating baseline levels of cell autophagy // American journal of translational

research. - 2019c. - Т. 11. - №. 7. - С. 4438-4449.

27. Linsley P. S. et al. Human B7-1 (CD80) and B7-2 (CD86) bind with similar

avidities but distinct kinetics to CD28 and CTLA-4 receptors // Immunity. - 1994.

Т. 1. - №. 9. - С. 793-801.

28. Liu H. et al. Increased expression of IDO associates with poor postoperative clinical

outcome of patients with gastric adenocarcinoma // Scientific Reports. -2016. - Т.

6. - №. 1. - С. 21319.

29. Lordick F. et al. Gastric cancer: ESMO Clinical Practice Guideline for diagnosis,

treatment and follow-up^ // Annals of Oncology. - 2022. - Т. 33. - №. 10. - С. 1005-

1020.

30. Lu S. et al. Expression of indoleamine 2, 3-dioxygenase 1 (IDO1) and tryptophanyl-

tRNA synthetase (WARS) in gastric cancer molecular subtypes // Applied

immunohistochemistry & molecular morphology: AIMM. - 2020. - T. 28. - №. 5. -

C. 360-368.

31. Ma W. et al. Targeting immunotherapy for bladder cancer by using anti-CD3x

CD155 bispecific antibody //Journal of Cancer. - 2019. - T. 10. - №. 21. - C. 5153-

5161.

32. Mai P. L. et al. Risks of first and subsequent cancers among TP53 mutation carriers

in the National Cancer Institute Li-Fraumeni syndrome cohort // Cancer. - 2016. -

T. 122. - №. 23. - C. 3673-3681.

33. Masciari S. et al. Gastric cancer in individuals with Li-Fraumeni syndrome //

Genetics in Medicine. - 2011. - T. 13. - №. 7. - C. 651-657.

34. McDermott D. et al. Efficacy and safety of ipilimumab in metastatic melanoma

patients surviving more than 2 years following treatment in a phase III trial

(MDX010-20) // Annals of Oncology. - 2013. - T. 24. - №. 10. - C. 2694-2698.

35. Möller-Hackbarth K. et al. A disintegrin and metalloprotease (ADAM) 10 and

ADAM17 are major sheddases of T cell immunoglobulin and mucin domain 3

(Tim-3) // Journal of Biological Chemistry. - 2013. - T. 288. - №2. 48. - C.

3452934544.

36. Moss M. L. et al. Recent advances in ADAM17 research: a promising target for

cancer and inflammation // Mediators of inflammation. - 2017. - T. 2017. C. 121.

37. Nakahara S., Raz A. Regulation of cancer-related gene expression by galectin-3 and

the molecular mechanism of its nuclear import pathway // Cancer and Metastasis

Reviews. - 2007. - T. 26. - № 3-4. - C. 605-610.

38. Ochs K. et al. Tryptophan-2, 3-dioxygenase is regulated by prostaglandin E2 in

malignant glioma via a positive signaling loop involving prostaglandin E receptor-

4 // Journal of neurochemistry. - 2016. - T. 136. - №. 6. - C. 1142-1154.

39. Okada K. et al. Reduced galectin-3 expression is an indicator of unfavorable

prognosis in gastric cancer // Anticancer research. - 2006. - T. 26. - №. 2B. - C.

1369-1376.

40. Parsonnet J. et al. Helicobacter pylori infection in intestinal-and diffuse-type gastric

adenocarcinomas // JNCI: Journal of the National Cancer Institute. - 1991. T. 83. -

№. 9. - C. 640-643.

41. Patel S. P., Kurzrock R. PD-L1 expression as a predictive biomarker in cancer

immunotherapy // Molecular cancer therapeutics. - 2015. - T. 14. - №2. 4. - C.

847856.

42. Peyraud F. et al. Targeting tryptophan catabolism in cancer immunotherapy era:

challenges and perspectives // Frontiers in Immunology. - 2022. - T. 13. - C. 807271.

43. Kuliev A.A., Juraev M.D. и др. // Turkish Journal of Physiotherapy and

Rehabilitation; 32(3) 2021. C 7242-7245

44. Кулиев А.А., Джураев М.Д. и др. // Academic research in educational sciences

scientific journal 2021. №2. C 291-307

45. Кулиев А.А., Джураев М.Д. и др. // Журнал биомедицины и практики; №2

2021. C 132-138.

46. Kuliev A.A., Juraev M.D. и др. // The American Journal of Medical Sciences and

Pharmaceutical Research (ISSN – 2689-1026) 2023. C 70-77.

##submission.downloads##

Nashr qilingan

2025-01-06

##submission.howToCite##

KULIEV Aziz Abdumazhidovich., & KHUJAKULOV Shakhriyor Shokirovich. (2025). SURGICAL PALLIATIVE AND SYMPTOMATIC TREATMENT OF REGIONAL CANCER OF THE CARDIOESOPHAGEAL JUNCTION . Ta’lim Innovatsiyasi Va Integratsiyasi, 36(4), 10-18. https://scientific-jl.org/tal/article/view/8959